SODIUM CYCLAMATE

SODIUM CYCLAMATE

SODIUM CYCLAMATE

CAS Number: 139-05-9
E number: E952 (iv) (glazing agents, …)
Chemical formula: C6H12NNaO3S
Molar mass: 201.22 g·mol−1

Sodium cyclamate (sweetener code 952) is an artificial sweetener.
Sodium cyclamate is 30–50 times sweeter than sucrose (table sugar), making it the least potent of the commercially used artificial sweeteners.
Sodium cyclamate is often used with other artificial sweeteners, especially saccharin; the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both sweeteners.
Sodium cyclamate is less expensive than most sweeteners, including sucralose, and is stable under heating.
Safety concerns led to Sodium cyclamate being banned in a few countries, though the European Union considers Sodium cyclamate safe.

Sodium cyclamate is the solid form of the artificial sweetener cyclamate.
Because of potential health concerns, cyclamate is currently banned by the U.S. Food and Drug Administration for consumption by humans.
However, cyclamate is currently being considered for reapproval due to its safe use in other countries.
Artificial sweeteners allow you to lower sugar in your diet, however, they should all be consumed in moderation.
Sodium Cyclamate is a white, odorless, free flowing crystalline powder used as a nonnutritive low-calorie sweetener choice ( but prohibited in some countries due to possible carcinogenic effects of its metabolic products).
Sodium cyclamate is freely soluble in water.
Sodium cyclamate is known about 30 times sweeter than sucrose.

Sodium cyclamate is  is an artificial sweetener.
Sodium cyclamate is 30-50 times sweeter than sucrose (table sugar), making it the least potent of the commercially used artificial sweeteners.
Sodium cyclamate did not saccharin consumption slightly bitter taste from time to time .
as an international common food additive can be used for soft drinks, fruit juices, ice cream, cakes and preserves food, etc.
Sodium cyclamate is the sodium salt of cyclamic acid and Sodium cyclamate is an artificial sweetener 30–50 times sweeter than sucrose.
Sodium cyclamate is stable under heating and Sodium cyclamates combination with saccharin is common to mask the off-tastes of both sweeteners.

Applications
Sodium Cyclamate is an artificial sweetener and is 30 times as saccharose′s.
Sodium cyclamate is widely used in pickles, seasoning sauce, cakes, biscuits, bread, ice cream, frozen sucker, popsicles, drinks and so on, with a maximum amount of 0.65g/kg.
Secondly, Sodium cyclamate is used in confect, with a maximum amount of 1.0g/kg.
Thirdly, Sodium cyclamate is used in orange peel, preserved plum, dried arbutus and so on, with the largest amount of 8.0g/kg.
Sodium cyclamate is also used in cosmetics and pharmaceutical industry.
Sodium cyclamate can be used as a sugar substitute in tabletop sweeteners (in table, powder or liquid form), in soft drinks,  seasonings, cakes, biscuits, bread,  ice cream, etc.
Sodium cyclamate is also used in pharmaceutical and personal care products (toothepaste, mouthwash) as a flavoring agent.

Solubility
Soluble in water (>=10 g/100 mL at 20°C).

Notes
Store away from oxidizing agents.
Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Sodium cyclamate is an artificial sweetener.
Sodium cyclamate is 30–50 times sweeter than sugar.
Sodium cyclamate is often used synergistically with other artificial sweeteners, especially saccharin; the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both sweeteners.
Sodium cyclamate is less expensive than most sweeteners, including sucralose, and is stable under heating.

What is Cyclamate?
Cyclamate is a synthetic artificial sweetener that is 30 to 50 times sweeter than sugar – the least sweet of all artificial sweeteners.
Cyclamate does leave an aftertaste, although less so than other artificial sweeteners such as saccharin.
Cyclamate is stable under heating and is commonly used in baked goods where other artificial sweeteners cannot be used.
Cyclamate is also combined with other sweeteners, particularly saccharin, to improve palatability.

Chemistry
Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by reacting freebase cyclohexylamine with either sulfamic acid or sulfur trioxide.
Prior to 1973, Abbott Laboratories produced sodium cyclamate (Sucaryl) by a mixture of ingredients including the addition of pure sodium (flakes or rods suspended in kerosene) with cyclohexylamine, chilled and filtered through a high speed centrifugal separator, dried, granulated and micro-pulverised for powder or tablet usage.

Preferred IUPAC name: Sodium cyclohexylsulfamate

Sodium and calcium cyclamates are used as non-nutritive sweeteners; sodium cyclamate, simply known as ‘cyclamate’, is the more common salt. Calcium cyclamate is used in low-sodium and sodium-free products.
World consumption of cyclamates in 1995 was estimated to be 15 000 tonnes.
Western European consumption of cyclamates was estimated to be 4000 tonnes.
Canadian consumption of cyclamates in 1995 was estimated to be 60 tonnes.
Consumption of sodium cyclamate in China in 1995 was estimated to be 4400 tonnes.

Use in Foods
While cyclamate isn’t allowed in the United States, Japan and 45 other countries, Sodium cyclamate is permitted in more than 80 countries, including European Union members.
Sodium cyclamate’s sometimes combined with saccharin in a 10-to-1 ratio to get the best of both sweeteners – saccharin because of Sodium cyclamates extreme sweetness and cyclamate because Sodium cyclamate has a more natural taste than saccharin and doesn’t have as much of an aftertaste.
Sodium cyclamate’s used in artificially sweetened beverages, including those that are water-based, milk-based and fruit-juice-based.

CAS Number: 139-05-9
ChEMBL: ChEMBL273977
ChemSpider: 8421
ECHA InfoCard: 100.004.863
E number: E952(iv) (glazing agents, …)
PubChem CID: 8751
UNII: 1I6F42RME1
CompTox Dashboard (EPA): DTXSID6020355

What’re the Uses of Sodium Cyclamate?
With the least sweetness, plus the US restriction, making sodium cyclamate not so popular among commercial artificial sweeteners.

This ingredient is used as a sugar alternative in sugar-free and low-calorie foods and beverages, also be used as a flavoring agent in pharmaceutical (as an excipient) and personal care products (e.g. toothpaste, mouthwash) to mask the unpleasant taste.

The following food may contain Sodium cyclamate:
-Table-top sweeteners in tablet, powder or liquid form
-Soft drinks
-Breakfast cereals
-Dairy products
-Cakes and baked products
-Dried fruits, preserved vegetables
-Nuts
-Jams, jellies and marmalades
-Chewing gum and candies
-Salad dressings

Benefits
-Zero glycemic index: suitable for diabetics without affecting blood sugar and insulin levels.
-Zero calories: as Sodium cyclamate is not metabolized for producing energy in the body.
-Teeth friendly: does not promote tooth decay.

Solubility
Soluble in water, practically insoluble in ethanol, and insoluble in most organic solvents.

Taste
30 times as sweet as sugar, so that only a little amount is needed to achieve the same sweet taste.
Without bitter aftertaste which occurs in sodium saccharin.

Sodium Cyclamate of the sweet and pure, 30 times the sweetness of sucrose,while the price of sugar is only 3 times.
Because a non-nutritive synthetic sweetener,so patients with diabetes, obesity can be the place of sugar.
Sodium Cyclamate unlike the slightly more when the amount of saccharin as bitter as the internationally accepted food additivescan be used for soft drinks, juices, ice cream, cakes and preserves food, etc.

Sodium cyclamate is white needle，flaky crystal or crystalline powder, odorless, sweet taste.
The dilute solution sweetness is about 30 times compares with sucrose.
The sweetness is 40~50 times that of sucrose, non nutritive sweeteners.
10% water solution is neutral (pH 6.5), stable with heat, light and air.
Sodium cyclamate tastes slightly bitter after heating.
The decomposition temperature of about 280°C, no caramelization reaction occurred.
A slight decomposition under the acidic environment, but stable in alkaline.
Sodium cyclamate can soluble in water (1g/5ml) and propylene glycol (1g/5ml), hardly soluble in ethanol, ether, benzene and chloroform.
The concentration of more than 0.4% with a bitter taste, Sodium cyclamate will result odor like oil or rubber when the soluble in water with high content of nitrite and sulfite.

[Application]
Sodium cyclamate belongs to non nutritive sweeteners, the sweetness is 30 times that of sucrose, but the price is only 3 times of that of cane sugar.
Sodium cyclamate is not like saccharin taste bitter when we use sodium cyclamate a little more, and therefore as an international common food additives can be used in soft drinks, juice, ice cream, cakes and candied fruit etc.
Sodium cyclamate can also be used for family of seasoning, cooking, sauce dishes, sweet (cosmetics, syrup, sugar, sweet ingot, toothpaste, mouthwash, lipstick and other.
Diabetes, obesity can be used as a substitute for sugar.

SODIUM CYCLAMATE
139-05-9
Sodium cyclohexylsulfamate
Sodium N-cyclohexylsulfamate
Sulfamic acid, cyclohexyl-, monosodium salt
Cyclamic acid sodium salt
Cyclamate sodium
Assugrin
Asugryn
Ibiosuc
Suessette
Suestamin
Sugarin
Sugaron
sodium;N-cyclohexylsulfamate
Sodium sucaryl
Sucaryl sodium
Dulzor-Etas

Synonyms:
N-Cyclohexylsulfamic acid sodium salt, Cyclohexanesulfamic acid sodium salt, Sodium cyclamate, Sodium N-cyclohexylsulfamate, Cyclamic acid sodium salt, Sodium cyclohexanesulfamate

Cyclamate is an odorless, white crystalline powder.
The name usually denotes either calcium cyclamate or sodium cyclamate, both of which are salts of cyclohexylsulfamic acid.
They have a very sweet taste, with about 30 times the sweetening power of sucrose.

History
Cyclamate was discovered in 1937 at the University of Illinois by graduate student Michael Sveda. Sveda was working in the lab on the synthesis of an antipyretic drug.
He put his cigarette down on the lab bench, and when he put Sodium cyclamate back in his mouth, he discovered the sweet taste of cyclamate.
The patent for cyclamate was purchased by DuPont but later sold to Abbott Laboratories, which undertook the necessary studies and submitted a New Drug Application in 1950.
Abbott intended to use cyclamate to mask the bitterness of certain drugs such as antibiotics and pentobarbital.
In 1958, Sodium cyclamate was designated GRAS (Generally Recognized as Safe) by the United States Food and Drug Administration.

OTHER NAMES:
Monosodium cyclohexylsulfamic acid; sodium cyclohexanesulfamate

FORMULA:
C6H11NHSO3Na

ELEMENTS:
Carbon, hydrogen, nitrogen, sulfur, oxygen, sodium

COMPOUND TYPE:
Organic salt

STATE:
Solid

MOLECULAR WEIGHT:
201.22 g/mol

MELTING POINT:
265°C (509°F)

BOILING POINT:
Not applicable; decomposes

SOLUBILITY:
Soluble in water; insoluble in most organic solvents

The cyclamate family of compounds was discovered in 1937by Michael Sveda (1912–1999), then a graduate student at the University of Illinois.
Sveda was working on the development of new drugs to treat fever.
The story is that Sveda was smoking while he was working in the laboratory (a practice that would not be allowed today) and, at one point, he brushed some loose threads of tobacco from his lips.
As he did so, he noticed a very sweet flavor on the cigarette.
Curious as to the cause of the sweetness, Sveda looked more carefully into the compounds he was studying and eventually identified the source of the sweetness as a substance belonging to a class of compounds known as cyclamates.

The cyclamates are organic salts of the carboxylic acid cyclamic acid (C6H11NHSO3H).
The University of Illinois received a patent for the production of cyclamates, which they eventually sold to the DuPont chemical company.
DuPont, in turn, sold the patent to Abbott Laboratories, who first marketed the product in 1950.
The compound rapidly became very popular as an additive for diet foods and drinks.
Sodium cyclamate most formulations, Sodium cyclamate is mixed with saccharin, another artificial sweetener.
Saccharin is ten times as sweet as sodium cyclamate, but Sodium cyclamate leaves a metallic aftertaste that sodium cyclamate helps to mask.

Hachi-Sugar
Sodium cyclohexanesulfamate
Sucrum 7
UNII-1I6F42RME1
Cyclamate, sodium salt
Natriumzyklamate
Cyclohexylsulfamate sodium
CHEBI:82431
Cyclamate, sodium
Cyclamate sodium/ saccharin sodium
N-Cyclohexylsulfamic acid sodium salt
1I6F42RME1
Cyclohexanesulfamic acid, sodium salt
Cyclohexanesulfamic acid, monosodium salt
MFCD00003827
E952
Natrii cyclamas
Sodium cyclamate, 99%

Cyclamate was marketed in tablet form for use by diabetics as an alternative tabletop sweetener, as well as in a liquid form.
As cyclamate is stable to heat, Sodium cyclamate was and is marketed as suitable for use in cooking and baking.
In 1966, a study reported that some intestinal bacteria could desulfonate cyclamate to produce cyclohexylamine, a compound suspected to have some chronic toxicity in animals.
Further research resulted in a 1969 study that found the common 10:1 cyclamate–saccharin mixture increased the incidence of bladder cancer in rats.
The released study was showing that eight out of 240 rats fed a mixture of saccharin and cyclamates, at levels equivalent to humans ingesting 550 cans of diet soda per day, developed bladder tumors.

Sodium cyclamate, the second oldest artificial sweetener, which has the least sweetness – about 30 times sweeter than sucrose and with the European food additive number E952(ii).
This non-caloric sweetener can be used as a sugar substitute to reduce calorie and sugar intake in table-top sweeteners, soft drinks, baked goods, confections, and preserves.

Ciclamato sodico
Assurgrin feinsuss
Assurgrin vollsuss
Natrium cyclamicum
Cyclamate de sodium
Sulfamic acid, N-cyclohexyl-, sodium salt (1:1)
Natrium cyclohexylsulfamat
Natriumzyklamate [German]
Ciclamato sodico [DCIT]
Cyclohexylsulphamate sodium
Natriumcyclohexylamidosulfat
Sodium cyclohexyl sulfamate
Sodium cyclohexanesulphamate
Natraiumcyclohexylamidosulfat
Sodium cyclohexyl sulphamate
Sodium cyclohexylsulphamidate
Monosodium cyclohexylsulfamate
CCRIS 187

Sales continued to expand, and in 1969, annual sales of cyclamate had reached $1 billion, which increased pressure from public safety watchdogs to restrict the usage of cyclamate.
In October 1969, Department of Health, Education & Welfare Secretary Robert Finch, bypassing Food and Drug Administration Commissioner Herbert L. Ley, Jr., removed the GRAS designation from cyclamate and banned Sodium cyclamates use in general-purpose foods, though Sodium cyclamate remained available for restricted use in dietary products with additional labeling; in October 1970, the FDA, under a new commissioner, banned cyclamate completely from all food and drug products in the United States.
Abbott Laboratories claimed that its own studies were unable to reproduce the 1969 study’s results, and, in 1973, Abbott petitioned the FDA to lift the ban on cyclamate.
This petition was eventually denied in 1980 by FDA Commissioner Jere Goyan.
Abbott Labs, together with the Calorie Control Council (a political lobby representing the diet foods industry), filed a second petition in 1982.
Although the FDA has stated that a review of all available evidence does not implicate cyclamate as a carcinogen in mice or rats, cyclamate remains banned from food products in the United States.

Appearance: White solid
Brand Name: Assugrin;Sucaryl;Sugar Twin
CAS Number: 139-05-9
Density: 1.32 g/cm3
EINECS Number: 205-348-9
HS Code: 29299000
IUPAC Name: Sodium N-cyclohexylsulfamate
InChI: 1S/C6H13NO3S.Na/c8-11(9,10)7-6-4-2-1-3-5-6;/h6-7H,1-5H2,(H,8,9,10);/q;+1/p-1

Sodium Cyclamate is a white needle or flaky crystal or crystalline powder.
Sodium cyclamate is a non-nutritive synthetic sweetener which is 30 to 50 times sweeter than sucrose.
Sodium cyclamate is odorless, stable to heat, light, and air.
Sodium cyclamate is tolerant of alkalinity but slightly tolerant of acidity.
Sodium cyclamate produces pure sweetness without bitter taste.
Sodium cyclamate is widely used in different foods and is suitable for diabetic and obese patients.
Having a pure sweet taste, Sodium Cyclamate is the artificial sweetener and is 30 times as saccharose.
Sodium cyclamate can be widely used such as pickles, seasoning sauce, cakes, biscuits, bread, ice cream, frozen sucker, popsicles, drinks and so on, with a maximum amount of 0.65g/kg.
Secondly, Sodium cyclamate is used in confect, with a maximum amount of 1.0g/kg.
Thirdly, Sodium cyclamate is used in orange peel, preserved plum, dried arbutus and so on, with the largest amount of 8.0g/kg.

InChIKey: UDIPTWFVPPPURJ-UHFFFAOYSA-M
Melting Point: >300 °C
Molar Mass: 201.22 g/mol
Molecular Formula: C6H12NNaO3S
NFPA 704: H-2,F-1,R-0,C-NA
RTECS Number: GV7350000
Synonyms: Cyclohexanesulfamicacid, monosodium salt (8CI);Sulfamic acid, cyclohexyl-, monosodium salt (9CI);Acofarinas;Assugrin;Asugryn
Azucrona;Cyclamate sodium; Cyclohexylsulfamatesodium; Cyclohexylsulfamic acid sodium salt;Dulzor-Etas;Duplo-Sacarin
Hachi-Sugar;Ibiosuc;N-Cyclohexylsulfamic acid sodium salt;Natreen;Nutter

HOW IT IS MADE
Cyclamic acid is made by the sulfonation of cyclohexylamine.
Cyclohexylamine is a six-carbon ring compound with a single amine (-NH2) group attached to Sodium cyclamate.
Sodium cyclamates formula is C6H11NH2.
Sulfonation is the process by which an -SO2 group is added to a compound.
Sulfonation of cyclohexylamine is accomplished with either sulfur dioxide (SO2) or sulfamic acid (HOSO2NH2).

Natrii cyclamas [INN-Latin]
Sodium cyclohexyl amidosulphate
Cyclamate de sodium [INN-French]
N-Cyklohexylsulfamat sodny [Czech]
aminocyclohexylsulfonic acid, sodium salt
Cyclohexylsulfamic acid, sodium salt
EINECS 205-348-9
N-Cyklohexylsulfamat sodny
NSC 42195
sodiumcyclamate
Cyclohexylsulphamic acid, monosodium salt
Cyclohexanesulphamic acid, monosodium salt
AI3-24213
Sulfamic acid, cylclohexyl-, monosodium salt
Sodium cyclamate [INN:BAN:NF]
Sodium cyclamate (INN)
DSSTox_CID_355
ACMC-1B8DT

The petition is now held in abeyance, though not actively considered.
Sodium cyclamate is unclear whether this is at the request of Abbott Labs or because the petition is considered to be insufficient by the FDA.
In 2000, a paper was published describing the results of a 24-year-long experiment in which 16 monkeys were fed a normal diet and 21 monkeys were fed either 100 or 500 mg/kg cyclamate per day; the higher dose corresponds to about 30 cans of a diet beverage.
Two of the high-dosed monkeys and one of the lower-dosed monkeys were found to have malignant cancer, each with a different kind of cancer, and three benign tumors were found.
The authors concluded that the study failed to demonstrate that cyclamate was carcinogenic because the cancers were all different and there was no way to link cyclamate to each of them.
The substance did not show any DNA-damaging properties in DNA repair assays.

Sodium cyclamate is an artificial sweetener that’s 30 times as sweet as sugar.
The U.S. Food and Drug Administration banned Sodium cyclamate in 1969 due to concerns about Sodium cyclamates safety after an animal study showed a potential increased risk for cancer.
The FDA has yet to overturn this ban in spite of more recent research not showing this same risk, at least in part due to problems in determining a safe intake level.

C6H12NNaO3S
DSSTox_RID_75534
DSSTox_GSID_20355
SCHEMBL66221
Sodium N-Cyclohexanesulfamate
MLS004773942
CHEMBL273977
N-Cyclohexylsulfamic acid sodium
DTXSID6020355
bis(1-piperidinecarbodithioato)-zin
Tox21_202781
zinc-N-pentamethylene dithiocarbamate
ANW-20490
BDBM50500683
AKOS015897277
N-Cyclohexanesulfamic Acid Sodium Salt
CCG-213831

Sodium cyclamate is a non-nutritive synthetic sweetener, whose sweetness is 30 times that of sucrose, and the price is only one third of sucrose, and Sodium cyclamate does not have a little more bitter taste as saccharin, so it can be used as an international common food additive in cool drinks, fruit juices, ice cream, pastry food and preserves.
Cyclamate offer great tast
Cyclamate is about 30 to 40 times sweeter than sucrose.
Cyclamate provides an excellent taste and also has the ability to enhance flavors.
Also,Cyclamate are sometimes used as flavoring agents for many toothpastes, mouthwashes and pharmaceutical preparations,such as to mask the taste of unpleasant-tasting drugs.

CAS number: 139-05-9
EC number: 205-348-9
Grade: Ph Eur,BP
Hill Formula: C₆H₁₂NNaO₃S
Chemical formula: C₆H₁₂NO₃SNa
Molar Mass: 201.22 g/mol
HS Code: 2929 90 00

Sodium cyclamate Vs Calcium cyclamate
Cyclamates refer to salts of cyclamic acid (cyclohexylsulfamic acid), usually related to its sodium and calcium salts.
Sodium cyclamate is the most used form, while calcium cyclamate can be used as Sodium cyclamates replacement in low-sodium or sodium-free products.
The latter is not used widely as Sodium cyclamate will cause gelation and precipitation in some applications.
They can be produced by sulfonating cyclohexylamine with chlorosulfonic acid or sulfamate to cyclohexylsulfamate, then neutralization with NaOH or Ca(OH)2.

Other names: Sodium cyclohexylsulfamate, sodium cyclohexanesulfamate
CAS number: 139-05-9
Chemical formula: C6H12NNaO3S (anhydrous), C6H12NNaO3S·2H2O (dihydrate)
Molecular weight:
201.22 (anhydrous)
237.22 (dihydrate)

Sodium cyclamates food grade can be divided into anhydrous and dihydrate forms according to the content of crystal water.
The former (NF grade) is needle powder, while the latter (CP grade) with tablet appearance.

CAS Number: 139-05-9
Molecular Weight: 201.22
Beilstein Registry Number: 4166868
Linear Formula: C6H11NHSO3Na

SYNONYMS
Sodium cyclohexanesulfamate;
Cyclohexanesulfamic acid monosodium salt; Assugrin; Asugryn; Cyclohexylsulfamic acid monosodium salt; Hachi-sugar; Ibiosuc; Sodium cyclohexyl amidosulfate
Sodium cyclohexyl sulfamate; Sodium cyclohexylsulfamidate; Sodium N-cyclohexylsulfamate; N-Cyclohexylsulphamic acid sodium salt; Sodium sucaryl
Suessette; Suestamin; N-Cyklohexylsulfamat sodny; Natraiumcyclohexylamidosulfat; Other RN: 53170-91-5, 61373-78-2

Synonym(s):
N-Cyclohexylsulfamic acid sodium salt, Cyclohexanesulfamic acid sodium salt, Sodium cyclamate, Cyclamic acid sodium salt, Sodium cyclohexanesulfamate
Linear Formula: C6H11NHSO3Na
CAS Number: 139-05-9
Molecular Weight: 201.22
Beilstein/REAXYS Number: 4166868
EC Number: 205-348-9
MDL number: MFCD00003827
PubChem Substance ID: 57652301
NACRES: NA.22

Sodium cyclamate is an artificial sweetener.
Sodium cyclamate is 30 to 50 times sweeter than sugar.
Even though other artificial sweeteners are more potent, sodium cyclamate is often used because of Sodium cyclamates taste, which is close to natuarally occurring sugar.
Some studies have found that sodium cyclamate causes cancer.
For this reason, Sodium cyclamates use is forbidden in the United States.
In the European Union, the use in certain kinds of products is limited (to a maximal dose).

APPEARANCE: white crystals
ASSAY: 98.5% – 101.0%
pH: 5.5 – 7.0
FREE ACID: 0.3% max
SULFATE: 0.1% max
CYCLOHEXYLAMINE: 1ppm max
DICYCLOHEXYLAMINE: 10ppm max
ANILINE: 1ppm max
As: 3ppm max
Pb: 1ppm max
Se: 30ppm max
HEAVY MERALS: 10ppm max
LOSS ON DRYING: 0.5% max
ABSORPTION: 0.1 max (270nm)

Flavor: characteristic
Sugar Substitutes, Dairy Products, Confections, Baking Food, Yogurt, Desserts, Cookies, Juice, Soft Drink, Alcoholic Beverages, Beverage Powder, Chai Tea, Ice Cream, Dried Fruits, Gelatins, Puddings, Cosmetics, Pharmaceutical.

assay: ≥99.0% (T)
sweetness: 30 × sucrose
loss: ≤1.0% loss on drying
mp:>300 °C (lit.)
SMILES string: [Na+].[O-]S(=O)(=O)NC1CCCCC1
InChI: 1S/C6H13NO3S.Na/c8-11(9,10)7-6-4-2-1-3-5-6;/h6-7H,1-5H2,(H,8,9,10);/q;+1/p-1
InChI key: UDIPTWFVPPPURJ-UHFFFAOYSA-M

Cyclamate (E952):
Three different compounds are referred to as cyclamates: cyclamic acid, calcium cyclamate and sodium cyclamate.
Cyclamates, whether in the form of sodium cyclamate or calcium cyclamate, are stable in heat and cold and have good shelf-life.
The stability and solubility in water facilitate the use of cyclamates in foodstuffs and beverages.
Cyclamate has the lowest sweetening power of the intense sweeteners, but combined with other intense sweeteners, a synergistic effect masks the aftertaste associated with the use of a single sweetener.
The mixture of 10 parts cyclamate and one part of saccharin was widely used in foods and beverages during the 1960s.
In 1969, however, cyclamate was prohibited in many countries because bladder tumours were found in rats fed with the 10:1 cyclamate saccharin mixture.
Since then, several additional toxicity and carcinogenicity studies have been conducted with cyclamate, the cyclamate saccharin mixture and cyclamate meta- Safety aspects of sweeteners metabolite cyclohexylamine (CHA).

NCGC00164316-01
NCGC00260327-01
SODIUM (SULFONATOAMINO)CYCLOHEXANE
61373-78-2
AS-17602
CAS-139-05-9
S635
SMR003500667
FT-0624198
ST50997692
V0925
C19378
D02443
Q407786
J-007216
N-Cyclohexylsulfamic acid sodium 1000 microg/mL in Acetonitrile:Water

Cyclamate was synthesized in 1937 by a University of Illinois (U.S.) student by the name of Michael Sveda, who accidentally discovered its sweet taste.
The patent for cyclamate was first purchased by Dupont and then later sold to Abbott Laboratories.
The health care company’s reported interest in those days was to use the product to mask the bitter taste of an antibiotic and a pentobarbital elixir.
Abbott performed the necessary studies and submitted a New Drug Application for cyclamate in 1950.
Cyclamate was initially marketed as tablets that were recommended for use as a tabletop artificial sweetener for diabetics and others who had to restrict their intake of sugar.
In 1958, cyclamate was classified as GRAS (Generally Recognized as Safe) in the U.S.

SODIUM CYCLAMATE ANHYDROUS
Calorie-free sweetener for food & pharmaceutical use.
Sweetening power 30 to 50 timeshigher than sucrose.
Highly stable, good shelf-life, tooth-friendly and suitable for people with diabetes.
Very synergistic with other low-calorie sweeteners.
Main applications are soft-drinks, as excipient for pharmaceutical products, instant beverages, table-top sweeteners, confectionery, desserts, fine bakery.
Productos Aditivos supplies sodium cyclamate mainly to the high-end of the food market and to the pharmaceutical industry.
We have a unique position in this market, being the sole producer of sodium cyclamate in Europe, offering highest quality, service and flexibility.
Apart from our standard sodium cyclamate, we can also offer specialties to meet specific requirements of our customers, with for example specific mesh-sizes, higher purity, etc..
Our processes are certified ISO 9001, ISO 14000 and ISO 22000 + PAS 220, and regularly we are being audited by our customers.
We are proud to say that always we have been able to “pass the test”, which guarantees the correct establishment of these standards in the daily activity of our company.

Sodium Cyclamate is a calorie-free sweetener, 30 to 50 times sweeter than table sugar (sucrose).
With Sodium cyclamates special properties, Sodium Cyclamate has found a variety of applications in beverage, food, confectionery, bakery, pharmaceutical, health and personal care industry.
In some cases, Sodium cyclamate can also be blended with other artificial sweeteners to produce some special or favorable combinations of taste and sweetness.
Sodium Cyclamate has been approved as safe and fit for use in many countries, so Sodium cyclamate has widely been adopted as an ingredient or a food additive by many famous brands and companies across different industries.

Features of Sodium Cyclamate
Sweet without bitter or unpleasant aftertaste
Stable in heat, so suitable for cooking and baking
Soluble in water and acidic condition
Non-caloric
Economical for use
Blended Sweetener

We integrate our expertise in sweeteners and experience in manufacturing in order to develop our specialized techniques in blending different sweeteners.
With the proven techniques, we can produce and supply the blend of sodium cyclamate and saccharin, or the formulas of sodium cyclamate and other non-nutritive sweeteners at our factory to meet the specific taste and sweetness requirements.
Sodium cyclamate is also feasible for us to supply the blends at different ratios required by our customers.

Total Sweetening Solution
As a whole, we can supply and serve our customers with the full range of high intensity sweeteners including Saccharin, Aspartame and Acelsulfame-K.
We are confident that every customer can find a suitable sweetening agent or a specific blend in our product offerings to meet the requirements of his/her product development and to fulfill broader business purposes.

Industrial Chemicals
-Sulfamic acid
-Cyclohexylamine (CHA)
-Dicyclohexylamine (DCHA)

We supply sulfamic acid to paper pulp, pigment and dyestuff, and electroplating and aluminium industries.
Cyclohexylamine (CHA) can be used in rubber and related industries, and used for the process of water treatment, while dicyclohexylamine (DCHA) is specifically adopted as raw material for the manufacture of rubber accelerator and corrosion inhibitor in chemicals industry.

aminocyclohexylsulfonic acid, sodium salt
cyclamate sodium
cyclamate, sodium
Cyclamate, Sodium Salt
cyclamic acid sodium salt
cyclohexane sulfamic acid monosodium salt
cyclohexanesulfamic acid sodium salt
cyclohexanesulfamic acid, monosodium salt
cyclohexanesulfamic acid, sodium salt
cyclohexanesulphamic acid, monosodium salt
cyclohexyl sulfamic acid sodium salt
cyclohexylsulfamic acid monosodium salt
cyclohexylsulfamic acid sodium salt
N-cyclohexylsulfamic acid sodium salt
cyclohexylsulfamic acid, sodium salt
cyclohexylsulphamate sodium
cyclohexylsulphamic acid, monosodium salt
hachi-sugar

Selenium: ≤ 30 ppm
Sulphates: ≤ 500 ppm
Arsenic: ≤ 1 ppm
Lead: ≤ 1 ppm
Haevy Metals (as Pb): ≤ 10 ppm
Loss on drying:    ≤ 1%
Assay: ≥ 98,0%
pH value: 5,5 – 7,5

sodium cyclohexanesulfamate
monosodium cyclohexyl sulfamate
sodium cyclohexylsulfamate
monosodium cyclohexylsulfamate
sodium cyclohexylsulphamidate
sodium N-cyclohexylsulfamate
sodium sucaryl
sodiumcyclamate
sucaryl acid sodium salt
sucaryl sodium
sucrum 7
sulfamic acid, cyclohexyl-, monosodium salt
sulfamic acid, cylclohexyl-, monosodium salt
sulfamic acid, N-cyclohexyl-, sodium salt (1:1)

Assugrin; Assurgrin feinsuss; Assurgrin vollsuss; Asugryn; Ciclamato sodico; Ciclamato sodico [DCIT]; Cyclamate de sodium; Cyclamate de sodium [INN-French]
Cyclamate sodium; Cyclamate, sodium salt; Cyclamic acid sodium salt; Cyclohexanesulfamic acid, monosodium salt; Cyclohexanesulfamic acid, sodium salt
Cyclohexanesulphamic acid, monosodium salt; Cyclohexylsulfamate sodium; Cyclohexylsulfamic acid, sodium salt; Cyclohexylsulphamate sodium
Cyclohexylsulphamic acid, monosodium salt; Dulzor-Etas; Hachi-Sugar; Ibiosuc; Monosodium cyclohexylsulfamate; N-Cyklohexylsulfamat sodny [Czech]
Natraiumcyclohexylamidosulfat; Natreen; Natrii cyclamas; Natrii cyclamas [INN-Latin]; Natrium cyclamicum; Natrium cyclohexylsulfamat; Natriumcyclohexylamidosulfat
Natriumzyklamate [German]; Sodium N-cyclohexylsulfamate; Sodium cyclohexanesulfamate; Sodium cyclohexanesulphamate; Sodium cyclohexyl amidosulphate
Sodium cyclohexyl sulfamate; Sodium cyclohexyl sulphamate; Sodium cyclohexylsulphamidate; Sodium sucaryl; Sucaryl sodium; Sucrum 7; Suessette; Suestamin
Sugarin; Sugaron; Sulfamic acid, cylclohexyl-, monosodium salt

Sodium cyclamate [INN] [Wiki]
139-05-9 [RN]
168
1I6F42RME1
205-348-9 [EINECS]
61373-78-2 [RN]
aminocyclohexylsulfonic acid, sodium salt
ciclamato de sodio [Spanish] [INN]
cyclamate de sodium [French] [INN]
Cyclamate de sodium
Cyclamic acid sodium salt
Cyclohexanesulfamic acid sodium salt
Cyclohexanesulfamic acid, monosodium salt
Cyclohexylsulfamate de sodium [French] [ACD/IUPAC Name]
Cyclohexylsulfamic Acid Sodium Salt
GV7350000
MFCD00003827 [MDL number]

Sodium cyclamate is the solid form of the artificial sweetener cyclamate.
Because of potential health concerns, cyclamate is currently banned by the U.S. Food and Drug Administration for consumption by humans.
However, cyclamate is currently being considered for reapproval due to Sodium cyclamates safe use in other countries.

Monosodium cyclohexylsulfamate
natrii cyclamas [Latin] [INN]
Natriumcyclohexylsulfamat [German] [ACD/IUPAC Name]
N-Cyclohexylsulfamic acid sodium salt
SODIUM (SULFONATOAMINO)CYCLOHEXANE
Sodium cyclohexanesulfamate
Sodium cyclohexylsulfamate [ACD/IUPAC Name]
Sodium N-Cyclohexylsulfamate
Sucaryl Acid Sodium Salt
Sulfamic acid, cyclohexyl-, monosodium salt
Sulfamic acid, N-cyclohexyl-, sodium salt (1:1) [ACD/Index Name]
натрия цикламат [Russian] [INN]
سيكلامات صوديوم [Arabic] [INN]
环拉酸钠 [Chinese] [INN]
[139-05-9]
53170-91-5 [RN]
68476-78-8 [RN]
assugrin
assurgrin feinsuss
assurgrin vollsuss
asugryn

Uses of Sodium cyclamate:
Cyclamate (cyclohexylsulfamic acid and its calcium and sodium salts) were discovered in the United States in 1937.
They are 30 to 80 times as sweet as sucrose and were widely used until late 1969, when Sodium cyclamate was banned by the FDA because of questions on safety.
Sodium cyclamate is not banned in Canada and the European Union.
Cyclamate is produced by reacting cyclohexylamine with sulfonating agents, followed by reactions with sodium or calcium hydroxides to produce cyclamates and free cyclohexylamine as follows.
Owing to their good stability, cyclamates are suitable for all applications of intense sweeteners without a significant interfering taste sensation, and are heat stable.
The main application of cyclamates is in blends with saccharin in a 10:1 ratio by weight.
The mixture is more than twice as sweet as either component alone, making them an important sweetener in countries approving the use of both sweeteners.

Uses of Sodium cyclamate:
Sweetening agent.
Production Methods
Cyclamates are prepared by the sulfonation of cyclohexylamine in the presence of a base.
Commercially, the sulfonation can involve sulfamic acid, a sulfate salt, or sulfur trioxide.
Tertiary bases such as triethylamine or trimethylamine may be used as the condensing agent.
The amine salts of cyclamate that are produced are converted to the sodium, calcium, potassium, or magnesium salt by treatment with the appropriate metal oxide.

Beet molasses
ciclamato de sodio
Ciclamato sodico [Italian]
Cyclamate sodium
Cyclamate, Sodium
Cyclamate, Sodium Salt
Cyclohexanesulfamic acid, sodium salt
Cyclohexanesulphamic acid, monosodium salt
Cyclohexylsulfamate sodium
Cyclohexylsulfamic acid monosodium salt
Cyclohexylsulfamic acid, sodium salt
Cyclohexylsulphamate sodium
Cyclohexylsulphamic acid, monosodium salt

Sodium cyclamate is a high-intensity artificial sweetener derived from cyclamic acid.
“Cyclamate” is approved for food and beverage use in many countries, although the Food and Drug Administration (FDA) prohibits Sodium cyclamates use in the United States.
Some governments have requested that wines be analyzed for this compound prior to entry into their economies.

dulzor-etas
EINECS 205-348-9
hachi-sugar
ibiosuc
Molasses
Natraiumcyclohexylamidosulfat
Natreen
Natriumzyklamate [German]
N-cyclohexylsulfamate
N-Cyclohexylsulfamic acid sodium
N-Cyclohexylsulfamic acid sodium 1000 µg/mL in Acetonitrile:Water
N-Cyklohexylsulfamat sodny [Czech]

General Description
Odorless or almost odorless white crystals or crystalline powder.
Intensely sweet taste, even in dilute solution.
pH (10% solution in water): 5.5-7.5. Used as a non-nutritive sweetener.

Air & Water Reactions
Water soluble.

Reactivity Profile
Sodium N-cyclohexylsulfamate is incompatible with strong oxidizing agents, strong acids and strong bases.
Also incompatible with nitrites in acid solution.
Has only limited compatibility with potassium salts .

Aspartame and sodium cyclamate are semantically related in sugar substitute topic.
You can use “Aspartame” instead a noun phrase “Sodium cyclamate”.

Sodium [ACD/Index Name] [ACD/IUPAC Name] [Wiki]
SODIUM CYCLAMATE|SODIUM N-CYCLOHEXYLSULFAMATE
Sodium cyclohexanesulphamate
Sodium cyclohexyl amidosulphate
sodium cyclohexyl sulfamate
Sodium cyclohexyl sulphamate
Sodium cyclohexylsulphamidate
sodium sucaryl
sodium;N-cyclohexylsulfamate
sodiumcyclamate
Sucaryl [Trade name]
Sucaryl sodium
sucrosa
Sucrum 7
suessette
suestamin
sugarin
Sugaron
Sulfamic acid, cylclohexyl-, monosodium salt
UNII:1I6F42RME1
UNII-1I6F42RME1
натрия цикламат
سيكلامات صوديوم
环拉酸钠
甜蜜素 [Chinese]