Product name: Geniposidic acid
Synonym name: Premnosidic acid
Catalogue No.: BP0633
Cas No.: 27741-01-1
Formula: C16H22O10
Mol Weight: 374.342
Botanical Source: Genipa americana (genipap), Garrya elliptica and Premna barbata
Physical Description: Powder
Type of Compound: Iridoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Geniposidic acid, one of the main active ingredients in Gardenia jasminoides J. Ellis (Rubiaceae), has anti-atherosclerotic effects, can protect vascular endothelium and reverse plaque formation in an atherosclerotic model.[1]
Geniposidic acid and geniposide have antitumor effects , play a role in an effective anticancer product with the ability to decrease undesirable radiation damage to the hematologic tissue after high dose irradiation.[2]
Geniposidic acid can protect against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice.[3]
Geniposidic acid protects against anti-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2.[4]
Geniposidic acid has effects on the expression of MRP2 and BSEP in BRL-3A cells after FXR gene silencing mediated by si RNA.[5]
References:
[1] Yu G, Zi-Yu C, Xue L, et al. Pharm Biol, 2014, 53(2):1-6.
[2] Hsu H Y, Yang J J, Lin S Y, et al. Cancer Lett, 1997, 113(1-2):31-7.
[3] Kim S J, Kim K M, Park J, et al. J Ethnopharmacol, 2013, 146(1):271-7.
[4] Chen H, Huang X, Min J, et al. J Ethnopharmacol 2015, 179:197-207.
[5] Chen H, Shi S, Min J B, et al.China Journal of Traditional Chinese Medicine & Pharmacy, 2016,5.
[6] Peng M J, Zhang M, Liu J L, et al. Chinese Journal of Hospital Pharmacy, 2005, 25(04):300-2.