Product name: Luteoloside
Synonym name: Luteolin 7-glucoside; Glucoluteolin; Cinaroside; Cynaroside; Daphneflavonoloside; Flavopurposide
Catalogue No.: BP0899
Cas No.: 5373-11-5
Formula: C21H20O11
Mol Weight: 448.38
Botanical Source: Widespread in plants, e.g. in Salicaceae, Lamiaceae, Moraceae, Compositae, Leguminosae, Rosaceae, Gentianaceae. The commonest of all flavone glycosides
Physical Description: Yellow powder
Type of Compound: Flavonoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Luteolin-7-O-glucoside and luteolin at concentrations lower than 20 muM, significantly suppresses the productions of nitric oxide and prostaglandin E-2 (PGE(2)) in bacterial lipopolysaccharide activated-mouse macrophage RAW264.7 cells without introducing cytotoxicity; the inhibitory effects were further attributed to the suppression of both inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression, and not reduced enzymatic activity.[1]
Luteolin-7-O-glucoside from Ailanthus altissima has antiasthmatic activity through the downregulation of T helper 2 cytokine expression and inhibition of prostaglandin E2 production in an ovalbumin-induced asthma model.[2]
Luteolin-7-O-Glucoside can induce apoptosis by scavenging ROS and suppressing the expression of β-catenin in COLO 320 DM cells and effectively inhibit ACF development in DMH-induced experimental carcinogenesis, Hence it can be a potent anticancer drug for colon carcinogenesis.[3]
Luteolin-7-O-glucoside and luteolin can inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF-κB/AP-1/PI3K-Akt signaling cascades in RAW 264.7 cells.[4]
Luteolin-7-O-glucoside has anti-asthmatic activity, can suppress leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells.[5]
References:
[1] Hu C, Kitts D. Mol Cellr Biochem, 2004, 265(1-2):107-13.
[2] Jin M, Yang J H, Lee E, et al. Biol Pharm Bull, 2009, 32(9):1500-3.
[3] Baskar A A, Ignacimuthu S, Michael G P, et al. Nut Cancer, 2011, 63(1):130-8.
[4] Chungmu P, Song Y S. Nut Res Pract, 2013, 7(6):423-9.
[5] Jin M, Son K H, Chang H W. Biol Pharm Bull, 2011, 34(7):1032-6.
[6] Ling-Yun M A, Yao L W, Shuang-Cheng M A, et al. Chinese J Pharm Anal, 2009,29(9):1469-500.