PHENOXYETHANOL

PHENOXYETHANOL

PHENOXYETHANOL

CAS Number: 122-99-6; IUPAC name: 2-Phenoxyethanol; Phenoxyethanol; Ethylene glycol monophenyl ether; Phenoxytolarosol;Dowanol EP / EPH; Protectol PE; Emery 6705; Rose ether;1-Hydroxy-2-phenoxyethane
;β-hydroxyethyl phenyl ether; Phenyl cellosolve;Ethylene glycol phenyl ether;2-PHENOXYETHANOL; Cas No: 122-99-6; Phenoxyethanol; Ethylene glycol monophenyl ether; Ethanol, 2-phenoxy-; Phenyl cellosolve; Phenoxytol; Phenoxethol; Phenoxetol; Ethylene glycol phenyl ether; Phenoxyethyl alcohol
; 2-Phenoxyethan-1-Ol; 1-Hydroxy-2-phenoxyethane; Rose ether; Phenylmonoglycol ether; Arosol; Dowanol EP; 2-Phenoxyethyl alcohol; Glycol monophenyl ether; 2-Hydroxyethyl phenyl ether; Phenylglycol
;Fenyl-cellosolve; 2-Fenoxyethanol; Dowanol EPH; 2-Phenoxy-ethanol; Emery 6705; Emeressence 1160; Fenylcelosolv; Marlophen P; beta-Hydroxyethyl phenyl ether; 2-phenoxy ethanol;2-phenoxyethanol; Emuclens;Erisept; ethylene glycol monophenyl ether; phenoxethol; phenoxyethanol

2-Phenoxyethanol, also known as phenyl cellosolve or phenoxytol, belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring. 2-Phenoxyethanol exists as a solid, soluble (in water), and an extremely weak acidic (essentially neutral) compound (based on its pKa). 2-Phenoxyethanol has been detected in multiple biofluids, such as feces and saliva. Within the cell, 2-phenoxyethanol is primarily located in the cytoplasm. 2-Phenoxyethanol exists in all eukaryotes, ranging from yeast to humans. 2-Phenoxyethanol can be biosynthesized from phenol. 2-Phenoxyethanol is a potentially toxic compound.
Phenoxyethanol is a germicidal and germistatic glycol ether, phenol ether, and aromatic alcohol often used together with quaternary ammonium compounds.
Use: Phenoxyethanol is used as a perfume fixative; an insect repellent; an antiseptic; a solvent for cellulose acetate, dyes, inks, and resins; a preservative for pharmaceuticals, cosmetics and lubricants; an anesthetic in fish aquaculture; and in organic synthesis.

Phenoxyethanol is an alternative to formaldehyde-releasing preservatives.In Japan and the European Union, its concentration in cosmetics is restricted to 1%.
Production: Phenoxyethanol is produced by the hydroxyethylation of phenol (Williamson synthesis), for example, in the presence of alkali-metal hydroxides or alkali-metal borohydrides.
Efficacy: Phenoxyethanol is effective against gram-negative and gram-positive bacteria, and the yeast Candida albicans
Safety: Phenoxyethanol is a vaccine preservative and potential allergen, which may result in a nodular reaction at the site of injection. It reversibly inhibits NMDAR-mediated ion currents.
Ingestion may cause central nervous system and respiratory depression, vomiting and diarrhea in infants, particularly when combined with chlorphenesin

Phenoxyethanol, is the most commonly used globally-approved preservative in personal care formulations. It is extremely easy to use in most types of formulations and is chemically very stable. Phenoxyethanol
has a broad spectrum antimicrobial activity against bacteria, yeasts, and mold. The typical use level in formulations is 0,5 – 0,8%, and it is often combined with other preservatives, like Ethylhexyl glycerin, Hexylene glycol, Benzyl alcohol, Benzoic acid, Potassium
sorbate, Dehydroacetic acid, Chlorphenesin or Capryl glycol. The European Economic Community (EEC). Cosmetics Derivative and the Cosmetics Regulation of the European Union approved Phenoxyethanol in concentrations up 1%.
APPLICATIONS: Skin care – Make up – Hair care – Deodorant- ToiletriesCleansers- Sun care – Body care – Fragrances – Wet wipes
FORMULATION AND RECOMMENDATIONS: Phenoxyethanol, is the most commonly used globally-approved preservative in personal care formulations. It is extremely easy to use in most types of formulations and is chemically very stable. Phenoxyethanol
has a broad spectrum antimicrobial activity against bacteria, yeasts, and mold. The typical use level in formulations is 0,5 – 0,8%, and it is often combined
with other preservatives, like Ethylhexyl glycerin, Hexylene glycol, Benzyl alcohol, Benzoic acid, Potassium sorbate, Dehydroacetic acid, Chlorphenesin or Capryl glycol. The European Economic Community (EEC)
Cosmetics Derivative and the Cosmetics Regulation of the European Union approved Phenoxyethanol in concentrations up 1%.

Phenoxyethanol is used to preserve products from being contaminated. It has antifungal properties
It prevents the contamination of products by microbes. It boosts the efficacy of other preservatives and decreases the total amount of preservatives needed in a product. 

Description: Phenoxyethanol is a colorless, oily, paraben-free substance, which (mostly in combination with other preservatives) is applied to skin care products because of its bactericidal feature. The substance makes sure that the products have a longer shelf life and avoids excessive growth of bacteria caused by regular use. For example because of the opening and closing of the pot (oxidizing effect) or by extracting cream with the fingertips (bacterial effect).

Phenoxyethanol is used in parfumes as well in order to “fix” the fragrance.

The advantage of phenoxyethanol over other preservatives is that it is very stable, meaning that other ingredients, oxygen or light does not affect it. It has a broad spectrum that gives antibacterial protection. Many manufacturers of skin care products use phenoxyethanol, but often together with other preservatives. Often parabens.

However, there are brands that decide not to use parabens. They use phenyxyethanol in combination with natural preservatives like antioxidants from tocopherol (vitamin E), Azadirachta indica (Neem extract), Rosmarinus officinalis (rosemary) or rooibos extract. Sometimes a mixture of essential oils, potassium sorbate and citric acid is added. These are paraben free alternatives for the synthetic preservatives and ensure a durability of minimal 12 to 24 months.

By choosing natural preservatives in combination with phenoxyethanol, natural brands deliver safe, efficient and skin friendly products as well. Natural preservatives like anti oxidants have, besides that they avoid the formation of bacteria in crème, an anti-aging effect as well.

Recommended dosage: 0,5% – 1%, (possibly in combination with pure vitamin E)

Chemical formula: C8H10O2
Molar mass: 138.166 g·mol−1
Appearance: Colorless oily liquid
Odor: faint rose-like
Density: 1.102 g/cm3
Melting point: −2 °C (28 °F; 271 K)
Boiling point: 247 °C (477 °F; 520 K)
Solubility in water: 26 g/kg
Solubility: Chloroform, Alkali, diethyl ether: soluble
Solubility in peanut oil: slightly
Solubility in olive oil: slightly
Solubility in acetone: miscible
Solubility in ethanol: miscible
Solubility in glycerol: miscible
Vapor pressure: 0.001 kPa (0.00015 psi)
Thermal conductivity: 0.169 W/(m⋅K)
Refractive index (nD): 1.534 (20 ℃)

Phenoxyethanol is used as a preservative in cosmetic products and also as a stabilizer in perfumes and soaps. Exposure to phenoxyethanol has been linked to reactions ranging from eczema
 to severe, life-threatening allergic reactions. Infant oral exposure to phenoxyethanol can acutely affect nervous system function.

FOUND IN: Moisturizer, eye shadow, foundation, sunscreen, conditioner, mascara, eye liner, shampoo, lip gloss, concealer, body wash, hand cream, blush, hair color, hair spray, lip balm,
 lotion, nail polish, baby wipes, baby lotions and soaps, soap (liquid and bar), shaving cream, deodorant, toothpaste, fragrance, hair removal waxes, hand sanitizer and ultrasound gel.
WHAT IS PHENOXYETHANOL? Phenoxyethanol is used as a preservative in cosmetic products to limit bacterial growth. A review of 43 cosmetic products demonstrated that only 25 percent of 
the products had concentrations of phenoxyethanol greater than 0.6 percent and the mean concentration of phenoxyethanol was 0.46 percent.[5] Phenoxyethanol is also used as to stabilize 
components found in perfumes and soaps.

What Is It?
Phenoxyethanol is an oily, slightly sticky liquid with a faint rose-like scent. It is used as a preservative in a wide variety of both leave-on and rinse-off cosmetics and personal care products, including skin care, eye makeup, fragrances, blushers, foundations, lipstick, bath soaps, and detergents, among others. Phenoxyethanol has been reviewed by experts worldwide who have concluded it is safe as used in these products.

Why is it used in cosmetics and personal care products?
Phenoxyethanol has been used safely since the 1950s as a preservative in cosmetics and personal care products. It is highly effective in preventing the growth of fungi, bacteria, and yeast that could cause products to spoil, just like food. The use of preservatives enhances products’ shelf life and safety.

Products that contain water are susceptible to mold, discoloration, or unpleasant odors caused by the bacteria and fungi naturally present in the environment. As cosmetics are used, they come in contact with the skin and applicators that contact the skin, thus potentially exposing the product to these harmful microorganisms.

Under certain conditions, an inadequately preserved product can become contaminated, which could cause health problems such as irritation or infection. Products contaminated by microorganisms may also negatively impact how the product performs, looks, feels, and smells. Preservatives like phenoxyethanol help prevent such problems.

2-phenoxyethanol is an aromatic ether that is phenol substituted on oxygen by a 2-hydroxyethyl group. It has a role as an antiinfective agent and a central nervous system depressant. It is a hydroxyether, a primary alcohol and an aromatic ether. It derives from a phenol.
Ethylene glycol phenyl ether is a colorless liquid with a pleasant odor. Density 1.02 g / cm3. An irritant.

Description
Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.

Chemical Properties
clear colorless liquid

Chemical Properties
Phenoxyethanol is a colorless, slightly viscous liquid with a faint pleasant odor and burning taste.

Characteristics
Phenoxyethanol is a tried-and-tested preservative, which is welltolerated by the skin and has a low allergy risk. It can be used over a wide pH range. This means that other preservatives can lose their effectiveness if the product is not within the right pH range. It does not smell unpleasant or change the color of the product, which can be the case when using natural antimicrobial substances.

Uses
phenoxyethanol is a broad-range preservative with fungicidal, bactericidal, insecticidal, and germicidal properties. It has a relatively low sensitizing factor in leave-on cosmetics. Phenoxyethanol can be used in concentrations of 0.5 to 2.0 percent, and in combination with other preservatives such as sorbic acid or parabens. In addition, it is used as a solvent for aftershaves, face and hair lotions, shampoos, and skin creams of all types. It can be obtained from phenol.

Uses
Ethylene glycol phenyl ether at a 1.0% level acts as a preservative in personal care products.

Uses
Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative.

Uses
Antimicrobial preservative; also used topically in treatment of bacterial infections.

Production Methods
Phenoxyethanol is prepared by treating phenol with ethylene oxide in an alkaline medium.

Synthesis Reference(s)
The Journal of Organic Chemistry, 40, p. 1356, 1975 DOI: 10.1021/jo00897a043

General Description
Colorless liquid with a pleasant odor. Density 1.02 g / cm3. An irritant.

Air & Water Reactions
Oxidizes in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Water soluble.

Reactivity Profile
2-Phenoxyethanol may react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.

Health Hazard
May cause moderate eye irritation and moderate corneal injury. Excessive exposure may cause skin irritation and hemolysis.

Fire Hazard
2-Phenoxyethanol is combustible.

Pharmaceutical Applications
Phenoxyethanol is an antimicrobial preservative used in cosmetics and topical pharmaceutical formulations at a concentration of 0.5–1.0%; it may also be used as a preservative and antimicrobial agent for vaccines.Therapeutically, a 2.2% solution or 2.0% cream has been used as a disinfectant for superficial wounds, burns, and minor infections of the skin and mucous membranes.
Phenoxyethanol has a narrow spectrum of activity and is thus frequently used in combination with other preservatives,

Industrial uses
2-Phenoxyethanol is used as a preservative in cosmetic formulations at a maximum concentration of 1.0%.
2-Phenoxyethanol is a broad spectrum preservative which has excellent activity against a wide range of Gram negative and Gram positive bacteria, yeast and mould. It is also used as a solvent and, because of its properties as a solvent, it is used in many blends and mixtures with other preservatives.
2-Phenoxyethanol is not registered as a food additive in the EU.
Scognamiglio et al. (ref. 105) reported that 2-phenoxyethanol is a fragrance ingredient used in many fragrance mixtures (see discussion). An ester of 2-Phenoxyethanol, 2-Phenoxyethyl isobutyrate and 2-Phenoxyacetic acid, the main metabolite of 2-Phenoxyethanol, were mentioned in a WHO publication where 43 flavouring agents in food were evaluated (WHO 2003, AR4), however at intakes assessed to be very low in Europe (around 1 µg/kg bw/day).

Contact allergens
Phenoxyethanol is an aromatic ether-alcohol used mainly as a preservative, mostly with methyldibromoglutaronitrile (in Euxyl? K 400) or with parabens. Sensitization to this molecule is very rare.

Safety Profile
Moderately toxic by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Some glycol ethers have dangerous human reproductive effects. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. To fight fEe, use CO2, dry chemical. Used as a solvent for ester-type resins. See also GLYCOL ETHERS.

Safety
Phenoxyethanol produces a local anesthetic effect on the lips, tongue, and other mucous membranes. The pure material is a moderate irritant to the skin and eyes. In animal studies, a 10% v/v solution was not irritant to rabbit skin and a 2% v/v solution was not irritant to the rabbit eye.Long-term exposure to phenoxyethanol may result in CNS toxic effects similar to other organic solvents.Safety issues related to preservatives used in vaccines, including 2-phenoxyethanol have been reviewed.Contact urticaria has been reported upon exposure to 2-phenoxyethanol-containing cosmetics.
The US FDA has recommended avoiding at least one topical product containing phenoxyethanol due to concerns over inadvertant exposure to nursing infants.
LD50 (rabbit, skin): 5 g/kg
LD50 (rat, oral): 1.26 g/kg

storage
Aqueous phenoxyethanol solutions are stable and may be sterilized by autoclaving. The bulk material is also stable and should be stored in a well-closed container in a cool, dry place.

Incompatibilities
The antimicrobial activity of phenoxyethanol may be reduced by interaction with nonionic surfactants and possibly by absorption by polyvinyl chloride.The antimicrobial activity of phenoxyethanol against Pseudomonas aeruginosa may be reduced in the presence of cellulose derivatives (methylcellulose, sodium carboxymethylcellulose, and hypromellose (hydroxypropylmethylcellulose)).

Regulatory Status
Included in the FDA Inactive Ingredients Database (topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Under European regulations for cosmetics (76/768/EEC), the maximum authorized concentration (MAC) of 2-phenoxyethanol is 1.0%.

Phenoxyethanol is a colorless, clear and oily liquid that is used in cosmetic products such as sunscreen and skin creams. Phenoxyethanol is produced by reaction between ethylene oxide and phenol at elevated pressure and temperature. Phenoxyethanol has intermediate water solubility and shows moderate evaporation rate. Phenoxyethanol is a bactericide and used simultaneously with ammonium compounds as a substitute for sodium azide due to its less toxic properties. In addition, phenoxyethanol is non reactive with lead and copper. It is used in numerous applications such as vaccines, cosmetics and pharmaceuticals products as a preservative. Phenoxyethanol is necessary to enhance the shelf life of cosmetics and personal care products. Phenoxyethanol can also be used as an alternative to potentially harmful formaldehyde-releasing preservatives. The activity of the preservative phenoxyethanol is effective in inactivating gram-positive and gram-negative microorganisms and yeast.

Phenoxyethanol is used in biological active agents such as bactericides, preservatives, fungicides, germicides, insect repellents and as an anesthetic agent. Phenoxyethanol is used in paints and coatings to improve fluidity, intensity, lustre and reduce film forming temperature. In addition, phenoxyethanol is used in perfumes as a fixative, as a solvent for inks, resins, dyes, pharmaceuticals and in organic synthesis. Furthermore, phenoxyethanol can be used as an anesthetic in the aquaculture of fish. Phenoxyethanol is listed as an ingredient for vaccines in the U.S., EU and Japan.

The continued expansion and growth of cosmetics industry is expected to increase consumption of phenoxyethanol. The increase in standard of living, rapid urbanization and rise in per capita income in emerging economies of Asia Pacific and Latin America is expected to boost spending on cosmetics and personal care products. Phenoxyethanol are popular as they are less toxic and have wide spectrum of antimicrobial activity. They are approved by the FDA for use in the cosmetics industry. However, availability of substitutes and government regulations could hamper the growth of this market. The future of preservatives in cosmetic industry is expected to be shaped by regulatory issues and consumer perception.

Asia Pacific is expected to the fastest growing market for phenoxyethanol due to increasing demand for cosmetics and personal care products. India and China are expected to be the largest consumers of phenoxyethanol due to presence of an established cosmetics industry. Republic of Korea, Japan, Taiwan, Malaysia and Indonesia are other major consumers of phenoxyethanol in Asia Pacific. In addition, emerging economies of Latin America and Middle East are expected to show incremental growth. Europe and North America are mature markets and expected to experience moderate to high growth.

2-PHENOXYETHANOL; Cas No: 122-99-6; Phenoxyethanol; Ethylene glycol monophenyl ether; Ethanol, 2-phenoxy-; Phenyl cellosolve; Phenoxytol; Phenoxethol; Phenoxetol; Ethylene glycol phenyl ether; Phenoxyethyl alcohol
; 2-Phenoxyethan-1-Ol; 1-Hydroxy-2-phenoxyethane; Rose ether; Phenylmonoglycol ether; Arosol; Dowanol EP; 2-Phenoxyethyl alcohol; Glycol monophenyl ether; 2-Hydroxyethyl phenyl ether; Phenylglycol
;Fenyl-cellosolve; 2-Fenoxyethanol; Dowanol EPH; 2-Phenoxy-ethanol; Emery 6705; Emeressence 1160; Fenylcelosolv; Marlophen P; beta-Hydroxyethyl phenyl ether; 2-phenoxy ethanol
Marlophen P 7
Spermicide 741
Tritonyl 45
Ethylan HB 4
EGMPE
Fenylcelosolv [Czech]
2-Fenoxyethanol [Czech]
Fenyl-cellosolve [Czech]
Plastiazan-41 [Russian]
Polyoxyethylene phenol ether
Polyoxyethylene phenyl ether
Phenol-ethylene oxide adduct
MFCD00002857
Glycols, polyethylene, monophenyl ether
Phenoxyethanol [NF]
Polyethylene glycol phenyl ether
.beta.-Hydroxyethyl phenyl ether
HSDB 5595
PHE-G
PHE-S
2-Phenoxyethanol, 99%
EINECS 204-589-7
9004-78-8
.beta.-Phenoxyethyl alcohol
alpha-Phenyl-omega-hydroxypoly(oxy-1,2-ethanediyl)
ethyleneglycol monophenyl ether
Phenoxyethanol (NF)
Poly(oxy-1,2-ethanediyl), alpha-phenyl-omega-hydroxy-
Erisept
Plastiazan-41
CAS-122-99-6
Phenol, ethoxylated
PHG
.beta.-Phenoxyethanol
phenoxy-ethanol
phenylcellosolve
Phenoxyethanolum
CCRIS 9481
Ethylene glycol-monophenyl ether
Dalpad A
2-phenyloxyethanol
Newpol EFP
2-Phenoxyethanol.
2-(phenoxy)ethanol
beta-Hydroxyphenetole
2-phenoxy-1-ethanol
beta-phenoxyethylalcohol
ACMC-1BVYG
2-Phenoxyethanol, 9CI
WLN: Q2OR
EC 204-589-7
SCHEMBL15708
2-Phenoxyethanol, >=99%
4-06-00-00571 (Beilstein Handbook Reference)
Euxyl K 400 (Salt/Mix)
[O]CCOC1=CC=CC=C1
2-PHENOXYETHANOL 500ML
Ethylene glycol mono phenyl ether
C(O)[C]OC1=CC=CC=C1
2-Phenoxyethanol, analytical standard
Fungal Terminator [veterinary] (TN)
Ethylene glycol monophenyl ether, >=90%
ETHANOL,2-PHENOXY MFC8 H10 O2
2-Phenoxyethanol, tested according to Ph.Eur.
Ethylene glycol monophenyl ether, SAJ first grade, >=95.0%
Phenoxyethanol, European Pharmacopoeia (EP) Reference Standard
Phenoxyethanol, United States Pharmacopeia (USP) Reference Standard
2-Phenoxyethanol, Pharmaceutical Secondary Standard; Certified Reference Material

GLOBAL REGULATORY
EU: EINECS) 204-589-7,(Annex I Index No.) 3-098-00-9
USA: (TSCA)Existing chemical
Canada: (DSL)
China: IECSC) Existing chemica
Japan: Existing chemical:(9)-1277, (3)-558
ASEAN (Indonesia, Malaysia, Philippines, Singapore,
Vietnam, Burma, Cambodia, Thailand, Laos, Brunei): (PICSS)
Existing chemical
South Korea: KE-28257 　　
Australia (NICNAS – Cosmetics): No limitation
New Zealand: HSR003045
PHENOXYETHANOL
SPECIFICATION
Description: Phenoxyethanol is an oily, slightly sticky
liquid with a faint rose-like odour. It is used as a preservative
in a wide variety of cosmetic and personal care products.
Research shows that this ingredient is safe when used in
these products.
INCI: Phenoxyethanol
EFFICACY
Escherichia coli (bacteria gram negative) -.32%
Pseudomonas aeruginosa (bacteria gram negative) -.32%
Staphylococcus aureus (bacteria gram positive) -.64%
Aspergillus niger (mold) -.32%
Candida albicans (yeast) -.32%

Phenoxyethanol is a glycol ether used as a preservative in cosmetic products. It is used in many skin care, make-up, hair care products. Because of its anti-bacterial properties, it is also used in baby wipes and hand sanitizer.
PHENOXYETHANOL is classified as :
Preservative
CAS Number    122-99-6
EINECS/ELINCS No:    204-589-7
Restriction (applies to EU only):    VI/29
COSING REF No:    36522
PHARMACEUTICAL EUROPEAN NAME: phenoxyethanolum
Chem/IUPAC Name: 2-Phenoxyethanol

Consumer products
Preservation of cosmetics, toiletry and household products and their raw materials. Phenoxyethanol is often used in combination with other preservatives and in some cases positive synergetic effects can be obtained. It is also used in acne treatment. Due to its low evaporation, Phenoxyethanol is used as a fixative in perfumes and fragrance.

Industrial products
It can be used in water mixable lubricants, in paints and varnishes as coalescing agent and as a modifier in melamine formaldehyde resins. It is used as a solvent in ball pen and printing inks. Phenoxyethanol is used as a striping agent and in the surface treatment of metals as degreaser. Its biostatic abilities is often used in combination with other actives to preserve metal working fluids, glues and industrial adhesives.

Safety
Eye contact may cause moderate irritation or moderate corneal injury. Repeated skin contact may result in absorption of harmful amounts. Swallowing small amounts is unlikely to result in injury. Swallowing large amounts may result in injury.
Phenoxyethanol is a high boiling liquid with a low vapor pressure, so exposure to vapors is unlikely at room temperature.
Phenoxyethanol  is thermally stable at typical storage and use temperatures. It can oxidize at elevated temperatures. Phenoxyethanol  is readily biodegradable and has a low potential for bioconcentration. It is practically nontoxic to aquatic organisms.

Handling and storage
Contact with eyes  and skin should be avoided. Safety googles must be worn when handling the concentrated product. The product should be stored at seald packaging as supplied, in dry conditions, at temperatures not exceeding 30
Classification according to UN criteria: Not classified as hazardous under transport regulation

Packaging & Shelf Life:
Under proper storage conditions the shelf life is 24 month.
 
Health & Safety:
Detailed information on the product can be found in our Material Safety Data Sheet.

Phenoxyethanol
Other
Translated names
2-fenoksietanol (hr)
2-Fenoksietanoli (fi)
2-fenoksietanolis (lt)
2-Fenoksietanols (lv)
2-fenoksyetanol (no)
2-fenoksüetanool (et)
2-Fenossietanol (mt)
2-fenossietanolo (it)
2-Fenoxietanol (es)
2-fenoxyetanol (sk)
2-fenoxyethan-1-ol (cs)
2-Fenoxyethanol (nl)
2-phenoxyethanol (da)
2-phénoxyéthanol (fr)
2-φαινοξυ-αιθανόλη (el)
2-φαινοξυαιθανόλ (el)
2-феноксиетанол (bg)
eter monofenylowy glikolu etylenowego (pl)
fenil glicol (it)
fenylglykol (sv)
fenoksietanol(tr)
fenoksi etanol (tr)
fenoksiethanol (tr)
fenoksi ethanol (tr)
CAS names: Ethanol, 2-phenoxy-
Other IUPAC names: 
1-HYDROXY-2-PHENOXYETHANE
2-(phenoxy)ethanol
2-(phenoxyethanol
2-Phenoxy-1-ethanol
2-phenoxyethan-1-ol
2-PhenoxyethanolRD_CLP_122-99-6_Ethanol, 2-phenoxy-_V1_20180112_TS
Ethylene glycol monophenyl ether
Ethylene glycol phenyl ether
 Ethyleneglycol monophenyl ether
SHINING COLOR BLUE EU CONC
Trade names
(2-hydroxy-ethyl)-phenyl-ether (alternative chemical name)
.beta.-Hydroxyethyl phenyl ether
.beta.-Phenoxyethanol
.beta.-Phenoxyethyl alcohol
2-Hydroxyethyl phenyl ether
2-Phenoxyethyl alcohol
Arosol
Beta-phenoxyethylalcohol (alternative chemical name)
Dalpad A
DALPAD™ A Coalescing Agent
Dowanol EP
Dowanol EPh
Dowanol EPH Glycol Ether
DOWANOL™ EPH Glycol Ether
DOWANOL™ EPH GLYCOL ETHER, EXTRA LOW PHENOL GRADE
ENSOLINE
Ethanol, 2-phenoxy- (6CI, 7CI, 8CI, 9CI)
Ethylene glycol monophenyl ether (alternative chemical name)
H 4644
MARLOPHEN P 1 AB
MARLOPHEN P 1 ABn
Marlosol PHE
Monophenylglykol
Phenoxethol
Phenoxetol
Phenoxyethanol (INCI name and CTFA adopted name)
Phenoxyethyl alcohol
Phenyl cellosolve
Protectol EPE (trade name)
Protectol PE (trade name)
SHINING COLOR BLUE, BR BLUE, LT BLUE EU CONC
STERO PE

Phenoxyethanol [Wiki]
122-99-6 [RN]
1-Hydroxy-2-phenoxyethane
204-589-7 [EINECS]
2-phenoxyethan-1-ol
2-Phenoxyethanol [ACD/IUPAC Name]
2-Phenoxyethanol [German] [ACD/IUPAC Name]
2-Phenoxy-ethanol
2-Phénoxyéthanol [French] [ACD/IUPAC Name]
DOWANOL(R) EPh
Ethanol, 2-phenoxy- [ACD/Index Name]
Ethylene glycol monophenyl ether
HIE492ZZ3T
KM0350000
PhE [Formula]
PHE-G
Phenoxyethanolum
PHENOXYETHYL ALCOHOL
Phenyl cellosolve
Phenylglycol
PHE-S
PHG
Rose ether
(2-Hydroxyethoxy)benzene
??2-phenoxyethanol
[122-99-6]
1219804-65-5 [RN]
134367-25-2 [RN]
18249-17-7 [RN]
2-(phenoxy)ethanol
200260-63-5 [RN]
21273-38-1 [RN]
268
2-Fenoxyethanol
2-Fenoxyethanol [Czech]
2-Hydroxyethyl phenyl ether
2-PHENOXY ETHANOL
2-Phenoxyethan-1-ol|(2-Hydroxyethoxy)benzene
2-phenoxyethanol 99%
2-phenoxyethanol, ??? 98.5%
2-phenoxyethanol, 94%
2-phenoxyethanol, 99%
2-Phenoxyethanol, 9CI
2-PHENOXYETHANOL-1,1-D2
2-Phenoxyethyl alcohol
2-Phenoxyethyl-1,1,2,2-d4 Alcohol
2-PHENOXYETHYL-2,2-D2 ALCOHOL
2-Phenoxyethyl–d4 Alcohol
37220-49-8 [RN]
4-06-00-00571 (Beilstein Handbook Reference) [Beilstein]
438620-17-8 [RN]
56257-90-0 [RN]
79586-53-1 [RN]
AI3-00752()C
Arosol
BB_SC-2741
C8H10O2
Dalpad A
Diethylene glycol monophenyl ether
Dowanol EP
Dowanol EPH
EGMPE
EINECS 204-589-7
Emeressence 1160
ETHANOL,2-PHENOXY MFC8 H10 O2
Ethylan HB 4
Ethylene glycol mono phenyl ether
ethylene glycol monobenzyl ether
ethylene glycol monophenyl ether 98%
ETHYLENE GLYCOL PHENYL ETHER
Ethylene glycol-monophenyl ether
Ethyleneglycol monophenyl ether
Ethyleneglycol-monophenyl ether
ETYLENEGLYCOL MONOPHENYL ETHER
Euxyl K 400 (Salt/Mix)
Fenyl-cellosolve
Fenyl-cellosolve [Czech]
Fenylcelosolv
Fenylcelosolv [Czech]
Glycol monophenyl ether
Glycols, polyethylene, monophenyl ether
http://www.hmdb.ca/metabolites/HMDB0041607
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:64275
InChI=1/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H
Jsp001544
Marlophen P
Marlophen P 7
NCGC00090731-02
NCGC00090731-03
Newpol EFP
Phenol, ethoxylated
Phenol-ethylene oxide adduct
Phenoxethol
Phenoxetol
Phenoxydiglycol
phenoxyethanol, reagent
Phenoxyethanol, USP-NF grade
Phenoxyl ethanol
Phenoxytol
Phenylcellosolve
Phenylmonoglycol ether
Plastiazan-41 [Russian]
Polyethylene glycol phenyl ether
Polyoxyethylene phenol ether
Polyoxyethylene phenyl ether
Spermicide 741
STR04582
Tritonyl 45
UNII:HIE492ZZ3T
UNII-HIE492ZZ3T
WLN: Q2OR
α-Phenyl-ω-hydroxypoly(oxy-1,2-ethanediyl)
β-Hydroxyethyl phenyl ether
β-Hydroxyethyl phenyl ether
β-Phenoxyethanol
β-Phenoxyethanol
β-Phenoxyethyl alcohol
β-Phenoxyethyl alcohol
苯氧乙醇 [Chinese]