Product name: Praeruptorin C
Synonym name: Wulongensin A
Catalogue No.: BP1135
Cas No.: 72463-77-5
Formula: C24H28O7
Mol Weight: 428.481
Botanical Source: Peucedanum spp., Musineon sp. and Seseli sp.
Physical Description: Powder
Type of Compound: Coumarins
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Praeruptorin C (Pra-C), one of the principal bioactive components derived from the root of Peucedanum praeruptorum Dunn, has been widely used as an antioxidant and a calcium antagonist to treat diseases, Pra-C partially also protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors and regulating the Bcl-2 family.[1]
Praeruptorin C can completely inhibit SMC proliferation induced by Ang II and partly inhibit the growth of SMC- induced by bovine serum, which is important in prevention and treatment of vascular hyperplastic disease.[2]
Praeruptorin C can attenuate the level of NCX mRNA , has cardioprotective effect on NCX mediates during ischemia/reperfusion in the neonatal rat cardiomyocytes I/R model; cardioprotection induced by hypoxia preconditioning and praeruptorin C preconditioning against hypoxia-reoxygenation injury may be related with upregulating phospholamban phosphorylation.[3,4]
References:
[1] Yang L, Li X B, Yang Q, et al. Toxicol in Vitro, 2013, 27(2):908-14.
[2] Wei E H, Rao M R, Chen X Y, et al.Acta Pharmacol Sin, 2002, 23(2):129-32.
[3] Qun-Ying X I, Zhu B H, Liu C, et al. Chinese Heart Journal, 2008(5):513-6.
[4] Chen K X, Zhu B H, Liu C. Chinese Journal of Geriatric Heart Brain & Vessel Diseases, 2008, 10(3):210-3.
[5] Xu G B, Liu S J, Liang Y M, et al.Traditional Chinese Medicine, 2007, 32 (19): 2069-71.